Zangiabadi Nasser, Ladino Lady Diana, Sina Farzad, Orozco-Hernández Juan Pablo, Carter Alexandra, Téllez-Zenteno José Francisco
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Front Neurol. 2019 Jun 6;10:601. doi: 10.3389/fneur.2019.00601. eCollection 2019.
Deep brain stimulation is a safe and effective neurointerventional technique for the treatment of movement disorders. Electrical stimulation of subcortical structures may exert a control on seizure generators initiating epileptic activities. The aim of this review is to present the targets of the deep brain stimulation for the treatment of drug-resistant epilepsy. We performed a structured review of the literature from 1980 to 2018 using Medline and PubMed. Articles assessing the impact of deep brain stimulation on seizure frequency in patients with DRE were selected. Meta-analyses, randomized controlled trials, and observational studies were included. To date, deep brain stimulation of various neural targets has been investigated in animal experiments and humans. This article presents the use of stimulation of the anterior and centromedian nucleus of the thalamus, hippocampus, basal ganglia, cerebellum and hypothalamus. Anterior thalamic stimulation has demonstrated efficacy and there is evidence to recommend it as the target of choice. Deep brain stimulation for seizures may be an option in patients with drug-resistant epilepsy. Anterior thalamic nucleus stimulation could be recommended over other targets.
深部脑刺激是一种治疗运动障碍的安全有效的神经介入技术。对皮质下结构进行电刺激可能会对引发癫痫活动的癫痫发作源产生控制作用。本综述的目的是介绍用于治疗药物难治性癫痫的深部脑刺激靶点。我们使用Medline和PubMed对1980年至2018年的文献进行了结构化综述。选择了评估深部脑刺激对药物难治性癫痫患者癫痫发作频率影响的文章。纳入了荟萃分析、随机对照试验和观察性研究。迄今为止，已在动物实验和人体中研究了对各种神经靶点的深部脑刺激。本文介绍了对丘脑前核和中央中核、海马体、基底神经节、小脑和下丘脑进行刺激的应用。丘脑前核刺激已证明有效，并有证据推荐将其作为首选靶点。对于药物难治性癫痫患者，深部脑刺激治疗癫痫可能是一种选择。与其他靶点相比，丘脑前核刺激可能更值得推荐。
Zotero 插件