利福平对抗葡萄球菌生物膜感染的作用：在动物模型和骨科器械相关感染中的作用。
Role of Rifampin against Staphylococcal Biofilm Infections , in Animal Models, and in Orthopedic-Device-Related Infections.
机构信息
Interdisciplinary Unit of Orthopaedic Infections, Kantonsspital Baselland, Liestal, Switzerland.
University of Basel, Basel, Switzerland.
出版信息
Antimicrob Agents Chemother. 2019 Jan 29;63(2). doi: 10.1128/AAC.01746-18. Print 2019 Feb.
Abstract
Rifampin has been used as an agent in combination therapy in orthopedic device-related infections (ODRI) for almost three decades. The aim of this review is to provide data regarding the role of rifampin against biofilm infection , in animal models, and in clinical ODRI. Available data are gathered in order to present the rational use of rifampin combinations in patients with periprosthetic joint infection (PJI). The role of rifampin is well defined in patients with PJI and is indicated in those who fulfill the Infectious Diseases Society of America criteria for debridement and implant retention or one-stage exchange. It should be used with care because of the danger of rapid emergence of resistance. Potential drug interactions should be considered.
摘要
利福平作为一种联合治疗药物，在骨科器械相关感染（ODRI）中已经应用了近三十年。本文的目的是提供有关利福平在生物膜感染、动物模型和临床 ODRI 中的作用的数据。收集现有数据是为了阐述利福平联合治疗在人工关节感染（PJI）患者中的合理应用。利福平在 PJI 患者中的作用已经明确，符合美国传染病学会清创和保留植入物或一期置换标准的患者需要使用。但是由于耐药性迅速出现的风险，应谨慎使用。还应考虑潜在的药物相互作用。
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