从恶性疟原虫中分离出一种26千道尔顿抗原并进行部分特性鉴定，该抗原可被一种抑制性单克隆抗体识别。

Isolation and partial characterisation of a 26 kilodalton antigen from Plasmodium falciparum recognised by an inhibitory monoclonal antibody.

作者信息

Ramasamy R, Simpson R J, Dexter A, Keeghan M, Reed C, Bushell G, Ingram L T, Henderson T, Moloney M B, Moritz R L

机构信息

Queensland Institute of Medical Research, Brisbane, Australia.

出版信息

Mol Biochem Parasitol. 1988 Jun;29(2-3):125-32. doi: 10.1016/0166-6851(88)90067-9.

DOI:10.1016/0166-6851(88)90067-9

PMID:3045539

Abstract

A 26 kDa protein, present in trophozoites and schizonts of Plasmodium falciparum, has been identified as the target of a monoclonal antibody that weakly inhibits parasite growth in vitro. The antigen has been purified to homogeneity by immuno-affinity chromatography and electrophoresis. The sequence of 19 amino acids at the N-terminus of the protein has been determined.

摘要

一种存在于恶性疟原虫滋养体和裂殖体中的26 kDa蛋白质，已被确定为一种单克隆抗体的靶标，该抗体在体外对寄生虫生长有微弱抑制作用。通过免疫亲和层析和电泳已将该抗原纯化至同质。已确定了该蛋白质N端19个氨基酸的序列。