Lino-Silva Leonardo S, Aguilar-Cruz Eduardo, Salcedo-Hernández Rosa A, Zepeda-Najar César
National Cancer Institute, Mexico City, Mexico.
Hospital Angeles, Tijuana, Mexico.
Contemp Oncol (Pozn). 2018;22(3):158-164. doi: 10.5114/wo.2018.78937. Epub 2018 Sep 30.
To analyse the influence of overweight and obesity in disease-specific survival (DSS) in rectal cancers at stages I-III in a population with high prevalence of overweight/obesity.
The population ( = 304) consisted of Mexican patients with stage I-III rectal cancer during the period between 2009 and 2015. Patients were divided based on their body mass index (BMI) into normal weight 18-25 kg/m, overweight 25-29 kg/m, and obesity BMI > 30 kg/m groups. Comparison of clinicopathologic features and survival analysis were performed.
The median age was 58 years (interquartile range [IQR] 50-65) and the mean BMI was 26.03 ±4.06 kg/m. Patients in the obesity and overweight groups received a lower proportion of preoperative treatment and had a higher proportion of patients in stage II. Overweight patients had a lower baseline neutrophil/lymphocyte ratio and lower survival rate than patients with normal weight and with obesity (mean survival of 69.5 months vs. 81.15 months and 86.4 months, respectively). The estimated five-year DSS was 51% for the overweight group, 81% for the normal group, and 82% for the obesity group ( = 0.026).
Patients with stage I-III rectal cancer in the overweight group showed a lower DSS compared to groups with normal weight and with obesity, with the last two being similar.
分析超重和肥胖对超重/肥胖高患病率人群中I - III期直肠癌患者疾病特异性生存（DSS）的影响。
研究人群（n = 304）由2009年至2015年期间患有I - III期直肠癌的墨西哥患者组成。患者根据体重指数（BMI）分为正常体重组（18 - 25kg/m²）、超重组（25 - 29kg/m²）和肥胖组（BMI＞30kg/m²）。对临床病理特征进行比较并进行生存分析。
中位年龄为58岁（四分位间距[IQR] 50 - 65），平均BMI为26.03±4.06kg/m²。肥胖组和超重组患者接受术前治疗的比例较低，II期患者比例较高。超重患者的基线中性粒细胞/淋巴细胞比值较低，生存率低于正常体重和肥胖患者（平均生存期分别为69.5个月、81.15个月和86.4个月）。超重组的估计五年疾病特异性生存率为51%，正常组为81%，肥胖组为82%（P = 0.026）。
超重的I - III期直肠癌患者与正常体重和肥胖患者相比，疾病特异性生存率较低，后两者相似。
