Lahma Jawad, Hejjouji Reda, Gicquel Philippe, Essakalli Leila
ENT Department, Ibn Sina University Hospital, Mohammed V University, Rabat, Morocco.
ENT Department, Hospital Center of Niort, France.
Pan Afr Med J. 2018 Jun 29;30:188. doi: 10.11604/pamj.2018.30.188.14992. eCollection 2018.
Large cell neuroendocrine carcinoma (LCNEC) is a rare but distinct entity of nasal cavity carcinomas. Only a very few cases have been reported in the nasal cavity. Its treatment is not well established. We report the case of a LCNEC in a 70 years old patient who presented with right nasal obstruction and epistaxis since 2 months. Diagnosis was confirmed by histological and immunohistochemical study. The patient underwent complete endoscopic removal of the tumor combined to adjuvant chemoradiotherapy. After 6 month follow-up, the patient was in complete clinical and radiological remission. We will discuss in this paper the various epidemiology, clinical features, pathological findings, differential diagnosis, and evolution of treatment of this uncommon malignancy in the light of current knowledge. Optimal treatment strategies are yet to be determined for this rare malignancy with poor prognosis including surgery and chemoradiotherapy.
大细胞神经内分泌癌（LCNEC）是鼻腔癌中一种罕见但独特的类型。鼻腔中仅有极少数病例报道。其治疗方法尚未明确。我们报告一例70岁患者的LCNEC病例，该患者自2个月前出现右侧鼻塞和鼻出血。通过组织学和免疫组化研究确诊。患者接受了肿瘤的完全内镜切除并联合辅助放化疗。经过6个月的随访，患者临床和影像学完全缓解。我们将根据现有知识，在本文中讨论这种罕见恶性肿瘤的各种流行病学、临床特征、病理表现、鉴别诊断及治疗进展。对于这种预后不良的罕见恶性肿瘤，包括手术和放化疗在内的最佳治疗策略仍有待确定。
