Wu Weiqi, Gan Puying, Xu Qihua, Wang Yaohua, Liao Hongfei
Department of Ocular Oncology and Ocular Trauma, Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Sciences, Key Laboratory of Ophthalmology of Jiangxi province.
Medical Department of Graduate School, Nanchang University, Nanchang, Jiangxi, China.
Medicine (Baltimore). 2020 Dec 4;99(49):e23502. doi: 10.1097/MD.0000000000023502.
Neuroendocrine carcinomas (NECs) are rare malignancies that originate from the hormone-producing cells of the neuroendocrine system. They can grow in most organs of the body but are commonly found in the gastrointestinal and respiratory tracts. The nasal cavity is a rare site for NECs.
We report a case of NECs in a 45-year-old woman who presented with epiphora in the right eye for a year owing to an unknown reason.
The diagnosis was initially confirmed via histological and immunohistochemical assays. Postoperatively, computed tomography of the neck revealed C4 vertebral bone metastasis.
The tumor was endoscopically removed from the right eye. The patient received a full course of adjuvant polychemotherapy.
Six months after diagnosis, the patient died due to bone metastasis.
Diagnosing nasal neuroendocrine carcinoma is clinically challenging. It must be distinguished from other orbital masses, such as chronic dacryocystitis or nasal polyps. The treatment should be further investigated for this rare malignancy in near future.
神经内分泌癌（NECs）是起源于神经内分泌系统激素产生细胞的罕见恶性肿瘤。它们可在身体的大多数器官中生长，但常见于胃肠道和呼吸道。鼻腔是神经内分泌癌的罕见发病部位。
我们报告一例45岁女性神经内分泌癌病例，该患者右眼流泪一年，原因不明。
最初通过组织学和免疫组化检测确诊。术后，颈部计算机断层扫描显示C4椎体骨转移。
通过内镜从右眼切除肿瘤。患者接受了全程辅助多药化疗。
诊断后六个月，患者因骨转移死亡。
诊断鼻腔神经内分泌癌在临床上具有挑战性。它必须与其他眼眶肿物，如慢性泪囊炎或鼻息肉相鉴别。对于这种罕见恶性肿瘤的治疗，在不久的将来应进一步研究。
