Uchida Naohiro, Tsuji Seijiro, Fujita Kohei, Koizumi Mitsuteru, Moriyoshi Koki, Mio Tadashi
Division of Respiratory Medicine, Center for Respiratory Disease National Hospital Organization Kyoto Medical Center Kyoto Japan.
Department of Nephrology National Hospital Organization Kyoto Medical Center Kyoto Japan.
Clin Case Rep. 2018 Oct 2;6(11):2185-2188. doi: 10.1002/ccr3.1848. eCollection 2018 Nov.
In the treatment of immunotherapy with immune checkpoint inhibitors, we often experience immune-related adverse event which manifest most frequently as a skin disorder, and very rarely as a renal disorder. In our manuscript, we report the case of a 71-year-old man with nivolumab-induced severe acute kidney injury (AKI) in which the time from treatment initiation to the onset of AKI was the longest among the previously reported cases (377 days). Prolonged follow-up is therefore warranted to detect late-onset AKI.
在使用免疫检查点抑制剂进行免疫治疗的过程中，我们经常会遇到免疫相关不良事件，其中最常见的表现为皮肤疾病，而肾脏疾病则极为罕见。在我们的论文中，我们报告了一例71岁男性患者，其因使用纳武单抗引发了严重急性肾损伤（AKI），在既往报道的病例中，从开始治疗到发生AKI的时间是最长的（377天）。因此，有必要进行长期随访以检测迟发性AKI。
