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膜性或膜样肾小球肾炎:一例大量蛋白尿、血清学阳性但活检时PLA2R阴性的病例报告

Membranous or membranous-like GN: A case report of massive proteinuria, positive serum with negative PLA2R on biopsy.

作者信息

Kaur Gurwant, Chen Guoli

机构信息

Department of Medicine (Nephrology) Penn State Milton S. Hershey Medical Centre Hershey Pennsylvania.

Department of Pathology Penn State Milton S. Hershey Medical Centre Hershey Pennsylvania.

出版信息

Clin Case Rep. 2018 Oct 9;6(11):2198-2201. doi: 10.1002/ccr3.1849. eCollection 2018 Nov.

Abstract

This case report represents primary membranous glomerulonephritis (MGN) with positive serum anti-PLA2R antibodies, 2+ positivity for IgG4 on immunofluorescence with routine fresh-frozen sections and negative PLA2R stain on biopsy. He was treated as primary MGN based on positive serum PLA2R and the absence of clinical symptoms or signs suggestive of any secondary MGN.

摘要

本病例报告为一例原发性膜性肾小球肾炎(MGN),血清抗磷脂酶A2受体(PLA2R)抗体阳性,常规新鲜冰冻切片免疫荧光显示IgG4呈2+阳性,活检时PLA2R染色阴性。基于血清PLA2R阳性且无提示任何继发性MGN的临床症状或体征,该患者被诊断为原发性MGN并接受治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b571/6230598/c38cd41d828e/CCR3-6-2198-g001.jpg

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