Moussawi Khaled, Meltzer Ethan I, Levin Seth N, Prasad Sashank
National Institute on Drug Abuse, Baltimore, MD 21224, United States.
Johns Hopkins Medicine, Department of Neurology, Baltimore, MD 21224, United States.
eNeurologicalSci. 2018 Nov 2;13:24-25. doi: 10.1016/j.ensci.2018.11.003. eCollection 2018 Dec.
Hypercalcemia from tumors has been associated with Posterior Reversible Encephalopathy Syndrome (PRES) but the mechanism remains unclear. In this article, we describe a case of PRES caused by hypercalcemia from lymphoma. We summarize the available scientific evidence linking hypercalcemia to failure of cerebral autoregulation and potentially PRES. A major link is the hypomagnesemia induced by hypercalcemia. While this concept requires further clinical testing and validation, it is clinically significant for the management of PRES, even when not directly caused by hypercalcemia.
肿瘤引起的高钙血症与后部可逆性脑病综合征（PRES）有关，但其机制尚不清楚。在本文中，我们描述了一例由淋巴瘤引起的高钙血症导致的PRES病例。我们总结了将高钙血症与脑自动调节功能衰竭以及潜在的PRES联系起来的现有科学证据。一个主要的联系是高钙血症引起的低镁血症。虽然这一概念需要进一步的临床测试和验证，但它对PRES的管理具有临床意义，即使PRES并非直接由高钙血症引起。
