Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Policlinico -Piazza G. Cesare, 11, 70124, Bari, Italy.
Inflamm Res. 2019 Feb;68(2):177-180. doi: 10.1007/s00011-018-1199-7. Epub 2018 Nov 19.
Hans Selye was an endocrinologist, a pioneer of research on biological stress in human individuals and groups. His most important scientific contributions include in 1936 the evidence that the pituitary-adrenal-thymus axis was activated by various nocuous stimuli, which led to the involution of the thymus and of the lymphoid organs; in 1946, the theory of general adaptation syndrome (GAS), pointing out that this is a general reaction that leads to resistance of the organism to various insults. This review article is focused on the general interest of Selye on the important role played by mast cells in different pathological conditions and in particular in calciphylaxis and calcergy, summarized in a classic book, which is a lasting contribution on the subject.
汉斯·塞利 (Hans Selye) 是一位内分泌学家，也是研究人类个体和群体生物应激的先驱。他最重要的科学贡献包括 1936 年的证据表明，各种有害刺激会激活垂体-肾上腺-胸腺轴，导致胸腺和淋巴器官退化；1946 年，一般适应综合征 (GAS) 理论指出，这是一种导致机体抵抗各种刺激的一般反应。这篇综述文章主要关注塞利对肥大细胞在不同病理情况下，特别是在钙化醇症和钙化症中的重要作用的普遍兴趣，这些内容总结在一本经典著作中，这是该领域的一项持久贡献。
