Department of Neuroscience, Virginia Polytechnic and State University, Blacksburg, Virginia.
Department of Neuroscience, Virginia Polytechnic and State University, Blacksburg, Virginia.
Biol Psychiatry. 2022 Jan 1;91(1):25-35. doi: 10.1016/j.biopsych.2021.02.003. Epub 2021 Feb 12.
The past decade has produced a plethora of studies examining sex differences in the transcriptional profiles of stress and mood disorders. As we move forward from accepting the existence of extensive molecular sex differences in the brain to exploring the purpose of these sex differences, our approach must become more systemic and less reductionist. Earlier studies have examined specific brain regions and/or cell types. To use this knowledge to develop the next generation of personalized medicine, we need to comprehend how transcriptional changes across the brain and/or the body relate to each other. We provide an overview of the relationships between baseline and depression/stress-related transcriptional sex differences and explore contributions of preclinically identified mechanisms and their impacts on behavior.
过去十年产生了大量研究，探讨应激和情绪障碍的转录谱中的性别差异。当我们从接受大脑中广泛的分子性别差异的存在转变为探索这些性别差异的目的时，我们的方法必须变得更加系统，而不是简化论。早期的研究已经研究了特定的大脑区域和/或细胞类型。为了利用这些知识开发下一代个性化药物，我们需要了解大脑和/或身体的转录变化如何相互关联。我们概述了基线和抑郁/应激相关转录性别差异之间的关系，并探讨了临床前确定的机制的贡献及其对行为的影响。
