Cellular Biology Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Virol Sin. 2019 Apr;34(2):162-167. doi: 10.1007/s12250-018-0061-y. Epub 2018 Nov 19.
Since the publication of the DRiP (defective ribosomal product) hypothesis in 1996, numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8 T cell immunosurveillance. Here, we review studies characterizing the generation of antigenic peptides from influenza A virus encoded DRiPs, discuss the many remaining mysteries regarding the nature of their co-translational generation, and speculate on where the future might lead.
自 1996 年 DRiP（缺陷核糖体产物）假说发表以来，许多研究都探讨了 DRiPs 对产生用于 CD8 T 细胞免疫监视的病毒抗原肽的贡献。在这里，我们回顾了描述从流感 A 病毒编码的 DRiPs 产生抗原肽的研究，讨论了关于它们共翻译生成性质的许多未解之谜，并推测未来的发展方向。
