Department of Pharmacy, Birla Institute of Technology & Science (BITS), Pilani, Rajasthan, India.
Department of Pharmacology, School of pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India.
Drug Dev Res. 2019 Mar;80(2):200-208. doi: 10.1002/ddr.21492. Epub 2018 Nov 19.
Microsponges are the spherical particles ranging from 5 to 300 μm in size. These are further made up of clusters of smaller spheres. They are designed for delivering the drug efficiently at a comparatively lesser dose and enhancing the stability, modifying the drug release profile and minimizing the side effects. Microsponge drug delivery system decrease transdermal invasion of the active ingredient into the skin while increasing the time the drug remains on the skin surface or within the epidermis. Preparation of the microsponges includes two techniques: Liquid-liquid suspension polymerization and Quasi-emulsion solvent diffusion method. Their characterization and evaluation can be done in many ways like particle-size measurement and porosity, morphology, true density determination, analyzing the rheological properties, and dissolution studies. Present work focuses on the detailed study of the microsponge drug delivery system. This will help the reader to get all the information regarding the microsponge delivery systems.
微球是一种粒径在 5 至 300μm 之间的球形颗粒。这些微球由更小的球体簇组成。它们旨在以相对较小的剂量高效地输送药物，增强药物稳定性、改变药物释放特性并最小化副作用。微球药物传递系统可减少活性成分经皮渗透进入皮肤，同时增加药物在皮肤表面或表皮内的停留时间。微球的制备包括两种技术：液-液相悬浮聚合和拟乳化溶剂扩散法。可以通过多种方法对其进行表征和评估，如粒径测量和孔隙率、形态、真密度测定、分析流变性能和溶解研究。本工作重点研究了微球药物传递系统。这将帮助读者获得有关微球传递系统的所有信息。
