Revision Skincare, Irving, Texas.
Tennessee Clinical Research Center, Nashville, Tennessee.
J Cosmet Dermatol. 2019 Feb;18(1):94-106. doi: 10.1111/jocd.12817. Epub 2018 Nov 19.
Skincare cosmeceutical products have been shown to address intrinsic and extrinsic skin aging. Radiofrequency (RF) with microneedling is effective and safe in improving skin laxity and texture. Pairing skincare cosmeceutical products pre- and post-procedure is beneficial as it enhances patient results, patient results, patient experience, and reduces patient downtime.
To evaluate the tolerability, safety, and efficacy of a multi-ingredient anti-aging facial moisturizer when applied pre- and post-procedure consisting of a single RF microneedling treatment.
Fifteen female patients, aged 37-60, Fitzpatrick skin types I-IV, with mild-to-moderate wrinkles were included in the study. Patients applied a multi-ingredient anti-aging facial moisturizer twice a day (morning and night) two weeks prior to RF microneedling and four weeks post-RF microneedling (twice a day). At each time point, investigator objective assessment, self-assessments, and clinical photography were taken.
There were no adverse events as evaluated by the investigator. For this combined treatment and procedure patient scored comfort as the highest for satisfaction. Tolerability parameters erythema and edema were reported after RF microneedling treatment and were significant compared to the pre-procedure timepoint. Eighty percent of patients showed an improvement in Glogau Wrinkle Scale, but improvement was not statistically significant between baseline and end of study. Improvements in all skin attributes (radiance, tone, smoothness, texture, redness, dryness, and overall appearance) were statistically significant at the end of the study. Self-perceived skin attribute improvements included overall improvement, brightness, texture, pigmentation, redness, and tightness. The combination of the anti-aging facial moisturizer and RF microneedling was recommended by the patients in this study.
This clinical study positively supports the hypothesis that combining the multi-ingredient anti-aging facial moisturizer pre- and post-RF microneedling was safe and tolerable for the patients.
护肤品化妆品已被证实可解决内在和外在的皮肤衰老问题。射频（RF）联合微针治疗对于改善皮肤松弛和质地非常有效且安全。在治疗前后使用护肤品化妆品可以增强患者的治疗效果、提升患者体验并减少患者的恢复期，这是有益的。
评估一种多成分抗衰老面部保湿霜在单次 RF 微针治疗前后使用的耐受性、安全性和疗效。
本研究纳入了 15 名年龄在 37-60 岁之间、Fitzpatrick 皮肤类型为 I-IV 型、有轻度至中度皱纹的女性患者。患者在 RF 微针治疗前两周和 RF 微针治疗后四周内，每天早晚两次使用多成分抗衰老面部保湿霜。在每个时间点，都进行了研究者的客观评估、自我评估和临床摄影。
研究者评估未发现不良事件。对于这种联合治疗和程序，患者对舒适度的评分最高，满意度最高。接受 RF 微针治疗后，红斑和水肿等耐受性参数有所报告，与治疗前时间点相比具有显著差异。80%的患者在 Glogau 皱纹量表上有改善，但与基线相比，改善无统计学意义。在研究结束时，所有皮肤属性（光泽度、色调、平滑度、纹理、红肿、干燥和整体外观）的改善均具有统计学意义。自我感知的皮肤属性改善包括整体改善、亮度、纹理、色素沉着、红肿和紧致度。在这项研究中，患者推荐使用抗衰老面部保湿霜和 RF 微针联合治疗。
本临床研究积极支持了以下假设，即在 RF 微针治疗前后联合使用多成分抗衰老面部保湿霜是安全且耐受的。
