Fernández José R, Webb Corey, Rouzard Karl, Voronkov Michael, Huber Kristen L, Stock Jeffry B, Healy Jason, Tamura Masanori, Stock Maxwell, Armbrister Wendi, Gordon Joel S, Pérez Eduardo
Signum Dermalogix, Princeton, New Jersey.
Department of Molecular Biology, Princeton University, Princeton, New Jersey.
J Cosmet Dermatol. 2019 Oct;18(5):1366-1371. doi: 10.1111/jocd.12825. Epub 2018 Nov 19.
SIG-1273 is a novel cosmetic active that provides a broad spectrum of benefits to the skin. Considering the chronic skin exposure to pollution in urban areas, we sought to determine if SIG-1273 could provide additional protection against skin aging by inhibiting pollutant-induced cytotoxicity and inflammation.
Determine if SIG-1273 possesses antipollution properties in vitro and evaluate the potential anti-aging benefits of Age IQ™ Night Cream clinically in human subjects.
In vitro studies utilizing normal human epidermal keratinocytes (NHEKs), were co-treated with urban dust (SRM 1649b) and SIG-1273 (toxicity protection measured by MTS assay). A water-soluble fraction of urban dust (UD-WS) induces pro-inflammatory cytokine release (IL-8) from NHEKs (measured via ELISA). An 8-week, 37-subject clinical trial was performed with 0.05% SIG-1273 formulated in Age IQ™ Night Cream and applied topically to assess its potential to reduce the appearance of aging.
In vitro studies using NHEKs demonstrate SIG-1273 protects against urban dust-induced cell toxicity, reducing cell death by 66% and concentration dependently inhibits UD-WS-induced IL-8 production (IC = 20 nmol/L), outperforming niacinamide, ascorbic acid, and α-tocopherol, commonly used actives in antipollution skin-care products. Clinical assessment of Age IQ™ Night Cream shows it is effective in improving the appearance of facial skin aging including fine lines and wrinkles, skin texture, skin clarity/brightness, and firmness/elasticity.
SIG-1273, is demonstrated here for the first time to possess antipollution properties. Included as a key active ingredient in Age IQ™ Night Cream, this novel topical formulation provides benefits to individuals with aging skin.
SIG - 1273是一种新型的化妆品活性成分，对皮肤有广泛益处。考虑到城市地区皮肤长期暴露于污染环境中，我们试图确定SIG - 1273是否能通过抑制污染物诱导的细胞毒性和炎症来提供额外的抗皮肤衰老保护。
确定SIG - 1273在体外是否具有抗污染特性，并在人体受试者中临床评估Age IQ™晚霜潜在的抗老化益处。
利用正常人表皮角质形成细胞（NHEK）进行体外研究，将其与城市灰尘（SRM 1649b）和SIG - 1273共同处理（通过MTS法测定毒性保护作用）。城市灰尘的水溶性部分（UD - WS）可诱导NHEK释放促炎细胞因子（IL - 8）（通过ELISA测定）。进行了一项为期8周、37名受试者的临床试验，将含0.05% SIG - 1273的Age IQ™晚霜局部涂抹，以评估其减少衰老迹象的潜力。
使用NHEK的体外研究表明，SIG - 1273可保护细胞免受城市灰尘诱导的细胞毒性，使细胞死亡减少66%，并浓度依赖性地抑制UD - WS诱导的IL - 8产生（IC = 20 nmol/L），优于抗污染护肤品中常用的活性成分烟酰胺、抗坏血酸和α - 生育酚。对Age IQ™晚霜的临床评估表明，它能有效改善面部皮肤衰老外观，包括细纹和皱纹、皮肤质地、皮肤清晰度/亮度以及紧致度/弹性。
本文首次证明SIG - 1273具有抗污染特性。作为Age IQ™晚霜的关键活性成分，这种新型局部用制剂对老化皮肤个体有益。
