Laboratory of Applied Microbiology, Department of Clinical and Toxicological Analysis, Federal University of Ceara (UFC), Fortaleza, Ceara, Brazil.
Laboratory of Manipulation I, Health Sciences Center, University of Fortaleza (UNIFOR), Fortaleza, Ceara, Brazil.
Curr Pharm Des. 2018;24(33):3951-3963. doi: 10.2174/1381612824666181120093634.
Essential oils (EOs) and their volatile components (VCs) have varied biological and pharmacological activities, but low solubility and bioavailability hamper their applications, so that inclusion in cyclodextrins (CDs) is likely to improve their physicochemical properties and pharmacological effects.
The authors conducted a systematic review to evaluate the biological activities and pharmacological applications of essential oils and their volatile components complexed with cyclodextrins.
The search terms 'Cyxlodextrin', 'Inclusion Complex', 'Volatile oils', 'Essential oil' and 'Volatile components' were used to retrieve articles from the PUBMED, MEDLINE and SCOPUS databases.
A total of 38 articles were identified. A greater efficacy of EOs and their VCs complexed with different CDs types was found in in vitro and preclinical studies when compared to free forms in the various biological activities and animal models of the evaluated pharmacological tests.
This review of selected studies showed that the use of CDs promotes greater solubility, bioavailability and efficacy of EOs and their VCs, thus indicating an interesting alternative for the biotechnological development of new therapeutic formulations.
精油（EOs）及其挥发性成分（VCs）具有多种生物学和药理学活性，但溶解度和生物利用度低，限制了它们的应用，因此将其包合于环糊精（CDs）中可能会改善其理化性质和药理作用。
作者进行了一项系统评价，以评估精油及其挥发性成分与环糊精形成包合物的生物学活性和药理学应用。
使用“Cyxlodextrin”、“Inclusion Complex”、“Volatile oils”、“Essential oil”和“Volatile components”等检索词从 PUBMED、MEDLINE 和 SCOPUS 数据库中检索文章。
共确定了 38 篇文章。与游离形式相比，在不同的生物学活性和评估的药理试验的动物模型中，用不同类型的 CD 包合的精油及其 VCs 的体外和临床前研究显示出更高的功效。
对选定研究的综述表明，使用 CDs 可提高精油及其 VCs 的溶解度、生物利用度和功效，这表明这是开发新治疗制剂的生物技术的一个有趣选择。
