Department of Quality Assurance, Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra, India.
Curr Drug Deliv. 2023;20(6):770-791. doi: 10.2174/1567201819666220630121939.
Volatile oils and their constituents have been considered major bioactive natural compounds due to their wide therapeutic and biological activities in pharmaceuticals in human healthcare. However, due to their poor solubility, their applications are limited. The inclusion complexation of volatile oils and their volatile constituents with cyclodextrins has emerged as a promising approach for the improvement of aqueous solubility, bioavailability, and stability.
The present review summarizes various research investigations highlighting the complexation of volatile oils and their constituents with cyclodextrins and their derivatives. Additionally, we present an overview of patents published between 1998-2021 to highlight the significance of including volatile oil in cyclodextrins.
The selection of articles for the current review was carried out by using keywords 'Cyclodextrin', 'Essential oil', 'Inclusion Complex', 'Encapsulation' and 'Essential oils/ volatile oils constituents' in certain specific databases, such as Elsevier (Science Direct), Pubmed Medical subject headings (MeSH) and Medline.
A total of 199 studies published were included in the review. In vitro and in vivo studies revealed the efficacy of EOs and their VCs complexed with various types of CD compared to free forms.
This review shows the impact of cyclodextrin complexation on the solubility, bioavailability, stability, and biological activities of volatile oils and their constituents.
挥发油及其成分因其在人类医疗保健中的广泛治疗和生物活性而被认为是主要的生物活性天然化合物。然而，由于其溶解度差，其应用受到限制。将挥发油及其挥发性成分与环糊精包合已成为提高其水溶性、生物利用度和稳定性的一种有前途的方法。
本综述总结了各种研究，强调了挥发油及其成分与环糊精及其衍生物的包合作用。此外，我们还概述了 1998 年至 2021 年期间公布的专利，以强调将挥发油纳入环糊精的重要性。
通过在特定数据库（如 Elsevier（Science Direct）、PubMed 医学主题词（MeSH）和 Medline）中使用关键字“Cyclodextrin”、“Essential oil”、“Inclusion Complex”、“Encapsulation”和“Essential oils/volatile oils constituents”，选择当前综述的文章。
共纳入 199 项已发表的研究。体外和体内研究表明，与游离形式相比，各种类型 CD 包合的 EO 和它们的 VC 具有更好的疗效。
本综述表明环糊精包合对挥发油及其成分的溶解度、生物利用度、稳定性和生物活性的影响。
