病例报告：中枢神经系统类圆线虫病：两例生前确诊。
Case Report: Central Nervous System Strongyloidiasis: Two Cases Diagnosed Antemortem.
机构信息
Division of Infectious Diseases, Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada.
Division of Infectious Diseases, Department of Medicine, St. Joseph's Health Centre, Toronto, Canada.
出版信息
Am J Trop Med Hyg. 2019 Jan;100(1):130-134. doi: 10.4269/ajtmh.18-0813.
Abstract
Central nervous system (CNS) strongyloidiasis is a known but rare form of disseminated infection. The diagnosis is often made postmortem, with only five published cases of an antemortem diagnosis. We report two fatal cases of CNS strongyloidiasis diagnosed antemortem, with larvae visualized in the CNS sample in one case. Risk factors for disseminated strongyloidiasis common to both cases included origination from the Caribbean, underlying human T-lymphotropic virus-1 infection, and recent prednisone use. Both cases occurred in Canada, where the occurrence of is uncommon, and serve as a reminder to maintain a high index of suspicion in patients with epidemiologic or clinical risk factors for dissemination.
摘要
中枢神经系统（CNS）旋毛虫病是一种已知但罕见的播散性感染形式。诊断通常是死后做出的，只有五例生前诊断的病例发表。我们报告了两例生前诊断的致命性中枢神经系统旋毛虫病病例，其中一例中枢神经系统样本中可见幼虫。两例均起源于加勒比地区，均有人类 T 淋巴细胞病毒 1 感染的潜在病因，并且近期使用过泼尼松，这些都是播散性旋毛虫病的常见危险因素。两例均发生在加拿大，那里不常见，这提醒我们要对具有流行病史或临床危险因素的患者保持高度怀疑。
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