Ritzl F, Tisljar U
Department of Nuclear Medicine, Klinikum Barmen, Wuppertal, FRG.
Nucl Med Commun. 1988 Jun;9(6):417-22. doi: 10.1097/00006231-198806000-00005.
The plasma clearance rate of 131I-insulin was studied in diabetic and obese patients and healthy persons. The aim of the investigation was to find out whether an accelerated degradation of insulin-probably due to the metabolism of insulin by adipocytes-causes slight forms of the diabetic syndrome. For the evaluation of the data a three-compartment model was used whereby the third compartment reflects the degradation of the intravenously administered 131I-insulin in the tissue. In this compartment 131I-insulin has a half life of 38.7 +/- 7.0 min for control persons (n = 19), 47.4 +/- 27.4 min for patients with a latent diabetes mellitus (n = 7), 34.2 +/- 8.5 min for the group with the subclinical diabetes (n = 5) and 47.6 +/- 16.2 min for the patients with an onset diabetes mellitus (n = 5). No significant difference was observed in the plasma clearance rate between healthy and diabetic persons. There is also no detectable correlation between the grade of obesity and the insulin clearance rate.
对糖尿病患者、肥胖患者和健康人进行了¹³¹I -胰岛素的血浆清除率研究。该研究的目的是确定胰岛素加速降解（可能是由于脂肪细胞对胰岛素的代谢）是否会导致轻度糖尿病综合征。为评估数据，使用了三室模型，其中第三室反映静脉注射¹³¹I -胰岛素在组织中的降解情况。在该室中，¹³¹I -胰岛素的半衰期在对照组（n = 19）为38.7±7.0分钟，潜伏性糖尿病患者（n = 7）为47.4±27.4分钟，亚临床糖尿病组（n = 5）为34.2±8.5分钟，糖尿病发病患者（n = 5）为47.6±16.2分钟。健康人和糖尿病患者之间的血浆清除率未观察到显著差异。肥胖程度与胰岛素清除率之间也未发现可检测到的相关性。
