Krušlin Božo, Vučić Majda, Mašić Silvija, Kruljac Ivan, Lež Cvjetko, Ružić Boris, Spajić Borislav, Ulamec Monika
Ljudevit Jurak Department of Pathology and Cytology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.
Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia.
Acta Clin Croat. 2018 Oct;57(Suppl 1):56-60. doi: 10.20471/acc.2018.57.s1.08.
LMO2 (LIM domain only) is a member of transcription factor family of proteins characterized by their cysteine-rich, zinc-binding LIM domains. Its expression in prostate cancer cells, as well as in adjacent stroma, is described in a study in a cohort of 83 patients treated with radical prostatectomy for clinically localized prostate adenocarcinoma. Authors found that LMO2 overexpression in prostate cancer was strongly associated with features indicative of worse prognosis (higher preoperative PSA, higher Gleason score, positive surgical margins, and extraprostatic extension of disease). Expression of LMO2 was also associated with biochemical disease progression. We analysed immunohistochemical expression of LMO2 in prostate cancer epithelial and stromal cells, as well as in adjacent parenchyma. Significant negative correlation between glandular expression of LMO2 in carcinoma and stromal expression in BPH (ρ = -0.238, P = 0.033) was found, but also be-tween stromal expression in carcinomas and glandular expression in BPH (ρ = -0.255, P = 0.021). Positive correlation was found between stromal expression in BPH and stromal expression in carci-nomas (ρ = 0.306, P = 0.005). Study results support the potential role of LMO2 in prostatic carcino-genesis and cancer progression.
LMO2（仅含LIM结构域）是转录因子蛋白家族的成员，其特征在于富含半胱氨酸的锌结合LIM结构域。在一项针对83例接受根治性前列腺切除术治疗临床局限性前列腺腺癌患者的队列研究中，描述了其在前列腺癌细胞以及相邻基质中的表达情况。作者发现前列腺癌中LMO2的过表达与提示预后较差的特征（术前PSA水平较高、Gleason评分较高、手术切缘阳性以及疾病前列腺外侵犯）密切相关。LMO2的表达还与生化疾病进展有关。我们分析了LMO2在前列腺癌上皮细胞、基质细胞以及相邻实质中的免疫组化表达。发现癌组织中LMO2的腺性表达与良性前列腺增生（BPH）中的基质表达之间存在显著负相关（ρ = -0.238，P = 0.033），癌组织中的基质表达与BPH中的腺性表达之间也存在负相关（ρ = -0.255，P = 0.021）。还发现BPH中的基质表达与癌组织中的基质表达之间存在正相关（ρ = 0.306，P = 0.005）。研究结果支持LMO2在前列腺癌发生和癌症进展中的潜在作用。
