Uslu Hasim, Kanra Ayşe Yağmur, Cetintas Gulgun, Tatar Mehmet Gurkan
Ophthalmic Surg Lasers Imaging Retina. 2018 Nov 1;49(11):846-851. doi: 10.3928/23258160-20181101-05.
To evaluate effect of continuous positive airway pressure (CPAP) therapy on choroidal thickness in patients with obstructive sleep apnea syndrome (OSAS).
Thirty distinct eyes of 30 patients with OSAS were evaluated right before and 12 months after CPAP treatment in this prospective observational study. Choroidal thickness was measured at the fovea and with periodic intervals of 500 µm from the foveal center in both temporal and nasal directions using spectral-domain optical coherence tomography in enhanced depth imaging mode.
The patients' mean age was 45.33 years ± 7.74 years, and there were eight females and 22 males. After CPAP therapy, the choroidal thicknesses were increased significantly at the subfoveal, 500 µm nasal to the fovea, 500 µm temporal to the fovea, and 1,000 µm temporal to fovea points (P < .05). However, none of retinal macular parameters were significantly different in statistical terms between the two measurements (P > .05).
CPAP therapy had a significant influence on choroidal thickness in patients with OSAS, providing an increase in choroidal thicknesses after 12 months. The determination of an increase in choroidal thickness may be useful to reveal the effects of CPAP therapy and also may be one of the mechanisms to improve choroidal function. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:846-851.].
评估持续气道正压通气（CPAP）治疗对阻塞性睡眠呼吸暂停综合征（OSAS）患者脉络膜厚度的影响。
在这项前瞻性观察研究中，对30例OSAS患者的30只患眼在CPAP治疗前及治疗12个月后进行评估。采用增强深度成像模式的光谱域光学相干断层扫描技术，在黄斑中心凹以及从黄斑中心向颞侧和鼻侧每隔500 µm处测量脉络膜厚度。
患者的平均年龄为45.33岁±7.74岁，其中女性8例，男性22例。CPAP治疗后，黄斑中心凹下、黄斑中心鼻侧500 µm处、黄斑中心颞侧500 µm处以及黄斑中心颞侧1000 µm处的脉络膜厚度均显著增加（P <.05）。然而，两次测量之间视网膜黄斑参数在统计学上均无显著差异（P >.05）。
CPAP治疗对OSAS患者的脉络膜厚度有显著影响，治疗12个月后脉络膜厚度增加。脉络膜厚度增加的测定可能有助于揭示CPAP治疗的效果，也可能是改善脉络膜功能的机制之一。[《眼科手术、激光与视网膜成像》。2018；49：846 - 851。]
