Nuotto E, Saarialho-Kere U
Department of Biochemistry, National Public Health Institute, Helsinki, Finland.
Pharmacol Toxicol. 1988 May;62(5):293-7. doi: 10.1111/j.1600-0773.1988.tb01890.x.
Objective and subjective effects on performance of single oral doses of indomethacin (IM) 50 mg and 100 mg and diazepam (DZ) 10-15 mg, alone and in combination, were investigated in two double-blind studies conducted with parallel groups of healthy drug-naive student volunteers. Objective and subjective effects were measured at baseline as well as 0.5 and 1.5 hours after treatment. DZ significantly impaired performance in digit symbol substitution, letter cancellation, tracking and flicker fusion tests. It also induced exophoria and caused subjective (visual analogue scales) drowsiness, mental slowness, clumsiness and impaired overall performance. IM proved rather inactive when slightly impairing flicker fusion and digit substitution, and subjectively rendering the subjects clumsier. The combined effects of IM and DZ did not differ from those obtained with DZ alone. Both IM and DZ induced dizziness and their effects in this respect were additive when the drugs were used in combination. It is concluded that single therapeutic doses of indomethacin do not produce major psychomotor effects and do not in this respect increase the effects of diazepam. However, the feeling of dizziness, a side-effect common to both these drugs, may be additive when the drugs are used in combination.
在两项针对健康、未使用过药物的学生志愿者平行组进行的双盲研究中，对单次口服50毫克和100毫克吲哚美辛（IM）以及10 - 15毫克地西泮（DZ）单独及联合使用时对性能的客观和主观影响进行了研究。在基线以及治疗后0.5小时和1.5小时测量客观和主观影响。地西泮在数字符号替换、字母划消、追踪和闪烁融合测试中显著损害性能。它还诱发外隐斜，并导致主观（视觉模拟量表）嗜睡、思维迟缓、笨拙和整体性能受损。吲哚美辛在轻微损害闪烁融合和数字替换时表现出相当不活跃，并且在主观上使受试者更笨拙。吲哚美辛和地西泮的联合作用与单独使用地西泮时获得的作用没有差异。吲哚美辛和地西泮都引起头晕，当联合使用这两种药物时，它们在这方面的作用是相加的。得出的结论是，单治疗剂量的吲哚美辛不会产生主要的精神运动效应，在这方面也不会增加地西泮的效应。然而，这两种药物共有的副作用头晕感，在联合使用时可能是相加的。
