Mattila M, Seppälä T, Mattila M J
Clin Pharmacol Ther. 1986 Dec;40(6):620-6. doi: 10.1038/clpt.1986.236.
The combined effects on performance of two anxiolytics with different mechanisms of action were evaluated double-blind and crossover in 12 healthy students. Objective (tracking, divided attention, Maddox wing, etc.) and subjective (visual analogue scales and questionnaires) tests were done before and twice after single oral doses. Diazepam (0.15 and 0.30 mg/kg) impaired performance dose relatedly and rendered the subjects drowsy, calm, mentally slow, and clumsy. Buspirone (15 mg) proved inactive in objective tests but matched diazepam (0.30 mg/kg) subjectively. In combinations, buspirone added to the effects of diazepam in Maddox wing and letter cancellation but tended to counteract diazepam effects on divided attention and learning acquisition. Subjectively buspirone prolonged diazepam-induced sedation. Increased calmness caused by diazepam was not affected by concomitant buspirone. It is suggested that combining small doses of buspirone to diazepam does not cause any additional decrement in psychomotor performance. Possible advantages of the diazepam-buspirone combination in therapeutic use are discussed.
在12名健康学生中，采用双盲交叉试验评估了两种作用机制不同的抗焦虑药对行为表现的联合影响。在单次口服给药前及给药后两次进行了客观（追踪、分散注意力、马多克斯翼试验等）和主观（视觉模拟量表和问卷）测试。地西泮（0.15和0.30mg/kg）按剂量相关地损害行为表现，使受试者困倦、平静、思维迟缓且动作笨拙。丁螺环酮（15mg）在客观测试中无活性，但在主观方面与地西泮（0.30mg/kg）相当。联合用药时，丁螺环酮增强了地西泮在马多克斯翼试验和字母划消试验中的效果，但倾向于抵消地西泮对分散注意力和学习获得的影响。在主观方面，丁螺环酮延长了地西泮引起的镇静作用。地西泮引起的平静程度增加不受同时使用丁螺环酮的影响。提示小剂量丁螺环酮与地西泮联合使用不会导致精神运动表现的额外下降。讨论了地西泮-丁螺环酮联合用药在治疗应用中的可能优势。
