Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, USA.
Department of Medical Microbiology and Immunology and Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Dev Cell. 2018 Nov 19;47(4):404-405. doi: 10.1016/j.devcel.2018.11.004.
Neutrophil migration to sites of injury or infection is a critical first step in innate immunity. Resolution of neutrophil inflammation is essential for tissue repair but is less well understood. Recent work using intravital imaging in mice to visualize neutrophil dynamics at sterile injuries has advanced our understanding of neutrophil reverse migration and resolution of inflammation in mammals.
中性粒细胞向损伤或感染部位的迁移是先天免疫的关键第一步。中性粒细胞炎症的解决对于组织修复至关重要,但了解较少。最近使用活体成像在小鼠中可视化无菌损伤中性粒细胞动力学的工作,推进了我们对哺乳动物中性粒细胞反向迁移和炎症消退的理解。