突触后 SNARE 蛋白：在突触传递和可塑性中的作用。
Postsynaptic SNARE Proteins: Role in Synaptic Transmission and Plasticity.
机构信息
Instituto de Neurociencias CSIC-UMH, 03550 San Juan de Alicante, Spain.
Instituto de Neurociencias CSIC-UMH, 03550 San Juan de Alicante, Spain.
出版信息
Neuroscience. 2019 Nov 10;420:12-21. doi: 10.1016/j.neuroscience.2018.11.012. Epub 2018 Nov 17.
Abstract
Soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins mediate membrane fusion events in eukaryotic cells. Traditionally recognized as major players in regulating presynaptic neurotransmitter release, accumulative evidence over recent years has identified several SNARE proteins implicated in important postsynaptic processes such as neurotransmitter receptor trafficking and synaptic plasticity. Here we analyze the emerging data revealing this novel functional dimension for SNAREs with a focus on the molecular specialization of vesicular recycling and fusion in dendrites compared to those at axon terminals and its impact in synaptic transmission and plasticity.
摘要
可溶性 N-乙基马来酰亚胺敏感因子附着蛋白受体 (SNARE) 蛋白在真核细胞中介导膜融合事件。传统上被认为是调节突触前神经递质释放的主要参与者，近年来积累的证据表明，几种 SNARE 蛋白参与了重要的突触后过程，如神经递质受体运输和突触可塑性。在这里，我们分析了揭示 SNARE 新功能维度的新兴数据，重点是与轴突末梢相比，树突中囊泡回收和融合的分子特异性及其对突触传递和可塑性的影响。
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