Department of Medicine, University of Wisconsin-Madison, Madison, WI; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI.
Department of Medicine, University of Wisconsin-Madison, Madison, WI; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI.
Urol Oncol. 2019 Aug;37(8):556-562. doi: 10.1016/j.urolonc.2018.10.010. Epub 2018 Nov 17.
Tumor-associated macrophages (TAMs) regulate an array of tumor functions and have critical roles in both the progression and the eradication of cancer. Numerous therapies targeting TAMs are under development in cancer and many have demonstrated success at the preclinical and clinical levels. Most of these therapies fall within 3 main categories: systemic depletion of TAMs, inhibition of TAM recruitment and polarization, and promoting the antitumor functions of TAMs. In this article, the rationale behind these various therapies and approaches is reviewed along with supporting preclinical and clinical data.
肿瘤相关巨噬细胞（TAMs）调节一系列肿瘤功能，在癌症的进展和消除中具有关键作用。目前有许多针对 TAMs 的治疗方法正在癌症领域开发中，其中许多在临床前和临床水平都取得了成功。这些疗法大多属于以下 3 种主要类型：全身性耗尽 TAMs、抑制 TAM 募集和极化，以及促进 TAMs 的抗肿瘤功能。本文回顾了这些不同疗法和方法的原理，以及支持它们的临床前和临床数据。
