Cohen E, Margalit I, Shochat T, Goldberg E, Krause I
Department of Medicine F - Recanati, Rabin Medical Center -Beilinson Hospital, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Department of Medicine F - Recanati, Rabin Medical Center -Beilinson Hospital, Petach Tikva, Israel.
Nutr Metab Cardiovasc Dis. 2019 Jan;29(1):9-14. doi: 10.1016/j.numecd.2018.09.003. Epub 2018 Sep 21.
High concentrations of homocysteine are considered a risk factor for atherosclerosis and coronary artery disease. The aim of this study was to assess whether or not there are gender differences in the plasma concentrations of homocysteine.
Data were collected from medical records of individuals examined at a screening center in Israel between the years 2000-2014. Cross sectional analysis was carried out on 9237 men and 4353 women. Mean (SD) age of the study sample was 48.4 (9.7) and 47.7 (9.7) years for men and women respectively. Average homocysteine concentrations were 12.6 (5.9) and 9.6 (3.2) μmol/L in men and women respectively (p < 0.001). Prevalence of homocysteine concentrations above 15 μmol/L was found to be significantly higher in men than in women; 15.5% vs 3.9% respectively (p < 0.001). Low concentrations of vitamin (B12 < 200 pmol/L) and low concentrations of folate (<12 nmol/L) were found to be significantly higher in men than in women 20.4% vs. 16.0% and 18.5% vs. 10.8% respectively. Compared to women, men had a significantly higher odds ratio (95% CI) of having homocysteine concentrations above 15 μmol/L: non adjusted model, 4.47 (3.80-5.26); adjusted model for age, smoking status, body mass index, diabetes mellitus, kidney function and low serum concentrations of vitamin B12 and folate, 3.44 (2.89-4.09).
Plasma homocysteine concentrations are higher in men than in women. This may be a contributing factor to gender differences for developing atherosclerosis and coronary artery disease.
高浓度同型半胱氨酸被认为是动脉粥样硬化和冠状动脉疾病的一个风险因素。本研究的目的是评估同型半胱氨酸的血浆浓度是否存在性别差异。
数据收集自2000年至2014年期间在以色列一个筛查中心接受检查的个体的病历。对9237名男性和4353名女性进行了横断面分析。研究样本的男性和女性平均（标准差）年龄分别为48.4（9.7）岁和47.7（9.7）岁。男性和女性的平均同型半胱氨酸浓度分别为12.6（5.9）和9.6（3.2）μmol/L（p < 0.001）。发现同型半胱氨酸浓度高于15μmol/L的患病率在男性中显著高于女性；分别为15.5%和3.9%（p < 0.001）。发现低浓度维生素（维生素B12 < 200 pmol/L）和低浓度叶酸（<12 nmol/L）在男性中显著高于女性，分别为20.4%对16.0%和18.5%对10.8%。与女性相比，男性同型半胱氨酸浓度高于15μmol/L的优势比（95%可信区间）显著更高：未调整模型，4.47（3.80 - 5.26）；针对年龄、吸烟状况、体重指数、糖尿病、肾功能以及低血清维生素B12和叶酸浓度进行调整后的模型，3.44（2.89 - 4.09）。
男性的血浆同型半胱氨酸浓度高于女性。这可能是动脉粥样硬化和冠状动脉疾病发生的性别差异的一个促成因素。
