Atilla Erden, Ataca Atilla Pınar, Cengiz Seval Güldane, Bektaş Mehmet, Demirer Taner
Department of Hematology, Ankara University School of Medicine, Cebeci Hospital, Ankara, Turkey.
Department of Gastroenterology, Ankara University School of Medicine, Cebeci Hospital, Ankara, Turkey.
Turk J Gastroenterol. 2019 Feb;30(2):122-131. doi: 10.5152/tjg.2018.18156.
The gastrointestinal (GI) system is one of the most commonly affected sites during a hematopoietic stem cell transplantation (HSCT) due to toxicities of preparative regimens, the accompanying immunodeficiency, and organ damage caused by graft versus host disease. In this review, we focus on early GI and liver complications following autologous (auto-) and allogeneic (allo-) HSCT and clarify both the risk factors and therapeutic strategies. Early GI and liver complications associated with HSCT remain challenging issues. Despite the improvements in this field during the last decade, treatments for these complications still place a significant burden on both patients and the physicians treating these patients. GI and liver complications remain some of the causes of mortality associated with HSCT. For practicing hematologists, oncologists, and gastroenterologists in this field, the awareness and early diagnosis of the GI complications remain important factors to obtain optimal outcomes in this patient population.
由于预处理方案的毒性、伴随的免疫缺陷以及移植物抗宿主病导致的器官损伤，胃肠道（GI）系统是造血干细胞移植（HSCT）过程中最常受影响的部位之一。在本综述中，我们聚焦于自体（auto-）和异基因（allo-）HSCT后的早期胃肠道和肝脏并发症，并阐明危险因素和治疗策略。与HSCT相关的早期胃肠道和肝脏并发症仍然是具有挑战性的问题。尽管在过去十年中该领域有所进展，但这些并发症的治疗仍然给患者和治疗这些患者的医生带来了沉重负担。胃肠道和肝脏并发症仍然是与HSCT相关的一些死亡原因。对于该领域的血液科医生、肿瘤内科医生和胃肠病学家而言，对胃肠道并发症的认识和早期诊断仍然是在这一患者群体中获得最佳治疗效果的重要因素。
