Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY
Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, China.
J Exp Med. 2018 Dec 3;215(12):2969-2971. doi: 10.1084/jem.20182034. Epub 2018 Nov 20.
In this issue of , the study by Chen et al. (https://doi.org/10.1084/jem.20181031) reveals a previously unrecognized role of cellular nucleic acid-binding protein (Cnbp) as a novel transcriptional regulator of interleukin-12β (IL-12β) transcription and IL-12-driven, Th1-mediated immune responses, which has important implications for both host defense and inflammatory disease.
本期《细胞》杂志中，Chen 等人的研究（https://doi.org/10.1084/jem.20181031）揭示了细胞核酸结合蛋白（Cnbp）作为白细胞介素-12β（IL-12β）转录和 IL-12 驱动的 Th1 介导免疫反应的新型转录调节剂的新作用，这对宿主防御和炎症性疾病都具有重要意义。
