Madeira Caroline, Vargas-Lopes Charles, Brandão Carlos Otávio, Reis Taylor, Laks Jerson, Panizzutti Rogerio, Ferreira Sergio T
Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Front Psychiatry. 2018 Nov 6;9:561. doi: 10.3389/fpsyt.2018.00561. eCollection 2018.
Recent evidence suggests that Alzheimer's disease (AD) and depression share common mechanisms of pathogenesis. In particular, deregulation of glutamate-mediated excitatory signaling may play a role in brain dysfunction in both AD and depression. We have investigated levels of glutamate and its precursor glutamine in the cerebrospinal fluid (CSF) of patients with a diagnosis of probable AD or major depression compared to healthy controls and patients with hydrocephalus. Patients with probable AD or major depression showed significantly increased CSF levels of glutamate and glutamine compared to healthy controls or hydrocephalus patients. Furthermore, CSF glutamate and glutamine levels were inversely correlated to the amyloid tau index, a biomarker for AD. Results suggest that glutamate and glutamine should be further explored as potential CSF biomarkers for AD and depression.
近期证据表明，阿尔茨海默病（AD）和抑郁症具有共同的发病机制。特别是，谷氨酸介导的兴奋性信号失调可能在AD和抑郁症的脑功能障碍中起作用。我们研究了确诊为可能的AD或重度抑郁症患者的脑脊液（CSF）中谷氨酸及其前体谷氨酰胺的水平，并与健康对照者和脑积水患者进行了比较。与健康对照者或脑积水患者相比，可能患有AD或重度抑郁症的患者脑脊液中谷氨酸和谷氨酰胺水平显著升高。此外，脑脊液中谷氨酸和谷氨酰胺水平与淀粉样蛋白tau指数呈负相关，淀粉样蛋白tau指数是AD的一种生物标志物。结果表明，谷氨酸和谷氨酰胺应作为AD和抑郁症潜在的脑脊液生物标志物进行进一步研究。
