Alterio Daniela, Marvaso Giulia, Ferrari Annamaria, Alessandro Ombretta, Cocorocchio Emilia, Ferrucci Pier Francesco, Orecchia Roberto, Jereczek-Fossa Barbara Alicja
Department of Radiation Oncology, European Institute of Oncology, Milano, Italy.
Medical Oncology of Melanoma, European Institute of Oncology, Milano, Italy.
BJR Case Rep. 2016 May 8;2(3):20150493. doi: 10.1259/bjrcr.20150493. eCollection 2016.
The prognosis of patients with metastatic melanoma is changing owing to the introduction of selective BRAF inhibitors combined with MEK inhibitors. Management of these patients continues to be a challenge, especially when systemic therapy has to be combined with concomitant radiotherapy, particularly owing to skin toxicity. Here we report a case of a patient who underwent concomitant treatment for two vertebral sites using two different radiotherapy techniques. An unexpected acute skin toxicity was reported at one of the treated sites. This finding might be owing to the different absorbed dose to the subcutaneous tissues linked with the technique of irradiation.
由于选择性BRAF抑制剂与MEK抑制剂联合应用，转移性黑色素瘤患者的预后正在发生变化。这些患者的管理仍然是一项挑战，尤其是当全身治疗必须与同步放疗联合应用时，特别是由于皮肤毒性。在此，我们报告一例患者，其使用两种不同的放疗技术对两个椎体部位进行同步治疗。在其中一个治疗部位报告了意外的急性皮肤毒性。这一发现可能归因于与照射技术相关的皮下组织吸收剂量不同。
