Matsumoto Tomohiro, Tomita Kosuke, Maegawa Shunto, Nakamura Takako, Suzuki Tetsuya, Hasebe Terumitsu
Department of Radiology, Tokai University Hachioji Hospital, Tokai University School of Medicine, 1838 Ishikawa-machi, Hachioji, Tokyo, 192-0032, Japan.
Center for Science of Environment, Resources and Energy, Graduate School of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa, 223-8522, Japan.
Cardiovasc Intervent Radiol. 2019 Mar;42(3):448-454. doi: 10.1007/s00270-018-2123-9. Epub 2018 Nov 20.
To describe the feasibility of lymphangiography and the visibility of the lymphatic system using post-lymphangiographic multidetector CT (MDCT) for preclinical lymphatic interventions in a rabbit model.
Lymphangiography via the popliteal lymph node or vessel after surgical exposure was performed, using six healthy female Japanese White rabbits. Lipiodol was manually injected for lymphangiography. Post-lymphangiographic MDCT examinations were performed in all rabbits. The dataset images were subjected to image processing analysis utilizing the three-dimensional maximum intensity projection technique. Three reviewers evaluated the degree of depiction of the lymphatic system using a four-point visual score (1, poor; 2, fair; 3, good; 4, excellent). The distance between the body surface and cisterna chyli was measured on post-lymphangiographic MDCT axial image.
Lymphangiography was successfully performed in all rabbits. The popliteal lymph node was detectable in 90%. The visualization of lymphatic system via the popliteal node was achieved in 89%. Mean visual scores of > 3.0 were realized by the right femoral lymphatic vessel, left femoral lymphatic vessel, left iliac lymphatic vessel, left lumbar lymphatic trunks and cisterna chyli, whereas mean visual scores of < 3.0 were yielded by the right iliac lymphatic vessel, right lumbar lymphatic trunks and thoracic duct. The distance between the body surface and cisterna chyli on post-lymphangiographic MDCT axial images was 4.33 ± 0.14 cm.
Lymphangiography is feasible, and the visibility of the lymphatic system on post-lymphangiographic MDCT in a rabbit model provides enough information for interventional radiologists to perform preclinical lymphatic interventions.
描述淋巴管造影的可行性以及使用淋巴管造影后多排螺旋CT（MDCT）在兔模型中进行临床前淋巴干预时淋巴系统的可视性。
对6只健康雌性日本白兔进行手术暴露后，经腘淋巴结或淋巴管进行淋巴管造影。手动注射碘油进行淋巴管造影。对所有兔子进行淋巴管造影后MDCT检查。利用三维最大强度投影技术对数据集图像进行图像处理分析。三名评估者使用四点视觉评分（1，差；2，一般；3，好；4，优秀）评估淋巴系统的描绘程度。在淋巴管造影后MDCT轴位图像上测量体表与乳糜池之间的距离。
所有兔子均成功进行了淋巴管造影。90%可检测到腘淋巴结。通过腘淋巴结实现了89%的淋巴系统可视化。右股淋巴管、左股淋巴管、左髂淋巴管、左腰淋巴干和乳糜池的平均视觉评分>3.0，而右髂淋巴管、右腰淋巴干和胸导管的平均视觉评分<3.0。淋巴管造影后MDCT轴位图像上体表与乳糜池之间的距离为4.33±0.14 cm。
淋巴管造影是可行的，兔模型中淋巴管造影后MDCT上淋巴系统的可视性为介入放射科医生进行临床前淋巴干预提供了足够的信息。
