Tanahashi Yukichi, Iwasaki Ryota, Shoda Shinichi, Kawada Hiroshi, Ando Tomohiro, Takasu Masaki, Hyodo Fuminori, Goshima Satoshi, Mori Takashi, Matsuo Masayuki
Department of Radiology, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan.
Department of Diagnostic Radiology and Nuclear Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.
Eur Radiol. 2020 Nov;30(11):5913-5922. doi: 10.1007/s00330-020-07031-0. Epub 2020 Jun 26.
To evaluate the optimal imaging protocol and the feasibility of intranodal dynamic contrast-enhanced computed tomography lymphangiography (DCCTL) in microminipigs.
The Committee for Animal Research and Welfare provided university approval. Five female microminipigs underwent DCCTL after inguinal lymph node injection of 0.1 mL/kg of iodine contrast media at a rate of 0.3 mL/min with three different iodine concentrations: group 1, 75 mgI/mL; group 2, 150 mgI/mL; and group 3, 300 mgI/mL. The CT values of the venous angle, thoracic duct (TD), cisterna chyli, iliac lymphatic duct, and iliac lymph node were measured; increases in CT values pre- to post-contrast were assessed as the contrast-enhanced index (CEI). Multi-detector row CT (MDCT) and volume rendering images showing the highest CEI were qualitatively evaluated.
The CEI of all lymphatics peaked at 5-10 min. The mean CEI of TD at 10 min of group 2 (193.0 HU) and group 3 (201.5 HU) were significantly higher than that of group 1 (70.7 HU) (p = 0.024). The continuity and overall diagnostic acceptability of all lymphatic system components were better in group 3 (3.6 and 3.0, respectively) than group 1 (2.6 and 1.6) and group 2 (3.0 and 2.6) (p = 0.249 and 0.204).
The optimal imaging protocol for intranodal DCCTL could be dual-phase imaging at 5 and 10 min after the injection of 300 mgI/mL iodinated contrast media. DCCTL provided good images of lymphatics and is potentially feasible in clinical settings.
• Dynamic contrast-enhanced computed tomography lymphangiography with intranodal injection of water-soluble iodine contrast media showed the highest enhancement of all lymphatics at scan delays of 5 and 10 min. • The optimal iodine concentration for intranodal dynamic contrast-enhanced computed tomography lymphangiography might be 300 mgI/mL. • Intranodal dynamic contrast-enhanced computed tomography lymphangiography provided good images of all the lymphatic system components and is potentially feasible in clinical settings.
评估微型猪体内淋巴结动态对比增强计算机断层扫描淋巴管造影（DCCTL）的最佳成像方案及可行性。
动物研究与福利委员会批准了本研究。五只雌性微型猪在腹股沟淋巴结注射0.1 mL/kg碘造影剂，注射速率为0.3 mL/min，使用三种不同碘浓度：第1组，75 mgI/mL；第2组，150 mgI/mL；第3组，300 mgI/mL。测量静脉角、胸导管（TD）、乳糜池、髂淋巴管和髂淋巴结的CT值；对比剂注射前后CT值的增加作为对比增强指数（CEI）进行评估。对显示最高CEI的多排螺旋CT（MDCT）和容积再现图像进行定性评估。
所有淋巴管的CEI在5 - 10分钟达到峰值。第2组（193.0 HU）和第3组（201.5 HU）在10分钟时TD的平均CEI显著高于第1组（70.7 HU）（p = 0.024）。第3组所有淋巴系统成分的连续性和总体诊断可接受性（分别为3.6和3.0）优于第1组（2.6和1.6）和第2组（3.0和2.6）（p = 0.249和0.204）。
淋巴结内DCCTL的最佳成像方案可能是在注射300 mgI/mL碘化造影剂后5分钟和10分钟进行双期成像。DCCTL能提供良好的淋巴管图像，在临床环境中可能可行。
• 淋巴结内注射水溶性碘造影剂的动态对比增强计算机断层扫描淋巴管造影在扫描延迟5分钟和10分钟时显示所有淋巴管的增强最高。• 淋巴结内动态对比增强计算机断层扫描淋巴管造影的最佳碘浓度可能为300 mgI/mL。• 淋巴结内动态对比增强计算机断层扫描淋巴管造影能提供所有淋巴系统成分的良好图像，在临床环境中可能可行。
