Faculty of Medicine in Hradec Králové, Charles University, Šimkova 870, Hradec Králové, Czech Republic.
Department of Pulmology, University Hospital in Hradec Králové, Sokolská 581, Hradec Králové, Czech Republic.
Arch Toxicol. 2019 Jan;93(1):1-9. doi: 10.1007/s00204-018-2356-z. Epub 2018 Nov 20.
Drug-induced cardiotoxicity is a serious problem associated with the administration of many drugs. MicroRNAs (miRNAs) have been reported to be affected by drugs and other xenobiotics, and the potential of miRNAs as biomarkers and diagnostic tools has been considered. In recent years, an association of certain miRNAs with the cardiotoxicity of some drugs, namely anthracyclines, bevacizumab, cyclosporine A and isoprenaline, has already been found. This review article summarizes available information about the changes in miRNA levels induced by cardiotoxic drugs. Three aspects are discussed: the altered expression of miRNAs in the heart upon treatment with cardiotoxic drugs, circulating miRNAs as promising early biomarkers of cardiotoxicity, and the potential of miRNAs in the prevention and/or attenuation of drug-induced cardiotoxicity. The targeted changes in the level of certain miRNAs by antagomiRs and miRNA mimics are also described and evaluated. In addition, the cardioprotective mechanism of various natural compounds via their effect on miRNA levels are examined.
药物性心脏毒性是与许多药物的应用相关的一个严重问题。已有报道称，微小 RNA（miRNA）可受药物和其他外源性物质的影响，因此人们考虑将 miRNA 作为生物标志物和诊断工具。近年来，已有研究发现某些 miRNA 与蒽环类药物、贝伐单抗、环孢素 A 和异丙肾上腺素等一些药物的心脏毒性之间存在关联。本文综述了与心脏毒性药物相关的 miRNA 水平变化的相关信息。讨论了三个方面：心脏毒性药物治疗后心脏中 miRNA 表达的改变、循环 miRNA 作为心脏毒性有前途的早期生物标志物，以及 miRNA 在预防和/或减轻药物性心脏毒性中的潜力。还描述和评估了 antagomiRs 和 miRNA 模拟物对某些 miRNA 水平的靶向改变。此外，还通过检查 miRNA 水平的变化来研究各种天然化合物的心脏保护机制。
