Mishra Satyendra, Patel Sejal, Halpani Chandni G
Medicinal Chemistry Laboratory, Center for Engineering and Enterprise, University and Institute of Advanced Research, Koba Institutional, Area Gandhinagar, Gujarat, 382426, India.
Chem Biodivers. 2019 Feb;16(2):e1800366. doi: 10.1002/cbdv.201800366. Epub 2019 Feb 4.
Curcumin is an admired, plant-derived compound that has been extensively investigated for diverse range of biological activities, but the use of this polyphenol is limited due to its instability. Chemical modifications in curcumin are reported to seize this limitation; such efforts are intensively performed to discover molecules with similar but improved stability and better properties. Focal points of these reviews are synthesis of stable pyrazole and isoxazole analogs of curcumin and application in various biological systems. This review aims to emphasize the latest evidence of curcumin pyrazole analogs as a privileged scaffold in medicinal chemistry. Manifold features of curcumin pyrazole analogs will be summarized herein, including the synthesis of novel curcumin pyrazole analogs and the evaluation of their biological properties. This review is expected to be a complete, trustworthy and critical review of the curcumin pyrazole analogs template to the medicinal chemistry community.
姜黄素是一种备受推崇的植物源化合物，已针对其多种生物活性进行了广泛研究，但由于其不稳定性，这种多酚的应用受到限制。据报道，对姜黄素进行化学修饰可克服这一限制；人们积极开展此类研究，以发现具有相似但稳定性更高且性能更优的分子。这些综述的重点是姜黄素稳定的吡唑和异恶唑类似物的合成及其在各种生物系统中的应用。本综述旨在强调姜黄素吡唑类似物作为药物化学中一种特殊骨架的最新证据。本文将总结姜黄素吡唑类似物的多种特性，包括新型姜黄素吡唑类似物的合成及其生物学特性评估。预计本综述将为药物化学界提供关于姜黄素吡唑类似物模板的全面、可靠且具批判性的综述。
