Lung Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Physiol. 2019 Jun;234(6):8496-8508. doi: 10.1002/jcp.27781. Epub 2018 Nov 21.
Psychiatric disorders are substantially associated with reduced quality of life and increased mortality. Depression and anxiety are two of the most common psychiatric disorders that often co-occur with each other as well as with other mental health conditions. Because of the limitations of currently available antidepressant therapies, there is a need for agents with improved efficacy and less adverse effects. Hypericum perforatum, widely known as St. John's wort, is a perennial herbaceous plant most well known for its antidepressant properties.
We reviewed the available in vitro, in vivo, and clinical evidence on the efficacy, safety, and mechanisms of action of St. John's wort and its active constituents in the treatment of psychiatric and neurodegenerative disorders.
Several interesting data have been reported about the antidepressant properties of H. perforatum in clinical trials with different designs. In particular, a number of antidepressant-controlled trials demonstrated that H. perforatum and its active ingredients, hypericin and hyperforin, possess antidepressant properties similar to those of tricyclic antidepressants and selective serotonin reuptake inhibitors but with fewer and milder side effects.
St. John's wort may exert potent antidepressant effects and represents an efficacious and safe treatment. However, the current clinical evidence regarding the efficacy of H. perforatum in other psychiatric and neurodegenerative disorders is not sufficient to draw a robust conclusion.
精神障碍与生活质量降低和死亡率增加密切相关。抑郁症和焦虑症是两种最常见的精神障碍，它们经常同时发生，并且还与其他心理健康状况同时发生。由于目前可用的抗抑郁治疗方法存在局限性，因此需要具有更好疗效和更少不良反应的药物。贯叶金丝桃，俗称贯叶连翘，是一种多年生草本植物，以其抗抑郁特性而闻名。
我们回顾了关于贯叶连翘及其活性成分在治疗精神和神经退行性疾病方面的疗效、安全性和作用机制的现有体外、体内和临床证据。
关于贯叶连翘在不同设计的临床试验中的抗抑郁特性，已经报告了一些有趣的数据。特别是，一些抗抑郁药对照试验表明，贯叶连翘及其活性成分金丝桃素和金丝桃苷具有与三环类抗抑郁药和选择性 5-羟色胺再摄取抑制剂相似的抗抑郁作用，但副作用更少且更轻微。
贯叶连翘可能具有有效的抗抑郁作用，是一种有效且安全的治疗方法。然而，目前关于贯叶连翘在其他精神和神经退行性疾病中的疗效的临床证据还不足以得出可靠的结论。
