Otero María Carolina, Ceric Francisco, Miranda-Rojas Sebastián, Carreño Carolina, Escares Rachelly, Escobar María José, Saracini Chiara, Atala Cristian, Ramírez-Barrantes Ricardo, Gordillo-Fuenzalida Felipe
School of Chemistry and Pharmacy, Faculty of Medicine, Andrés Bello University, Santiago 8370146, Chile.
Laboratory of Affective Neuroscience, Faculty of Psychology, Universidad del Desarrollo, Santiago 7610658, Chile.
Pharmaceuticals (Basel). 2024 Dec 3;17(12):1625. doi: 10.3390/ph17121625.
, also known as St. John's Wort, pericon, or yellow grass, is known for its antidepressant potential. It could represent a natural alternative to current pharmacological antidepressant treatments, which have a high incidence of side effects in patients and therefore lead to early dropouts. Through a bibliographic revision of clinical trials and information collected from scientific articles during the first period of 2020, we aimed to evaluate whether its administration could be beneficial in the treatment of mild-to-moderate depression, with fewer side effects compared to synthetic drugs. Among the main components, hypericin and hyperforin have been related to the observed antidepressant activity; therefore, their possible mechanism of action was reviewed and highlighted. Furthermore, patients receiving extracts were less likely to withdraw from studies because of adverse effects compared to those receiving older standard antidepressants. This review aims to provide suggestions for an alternative treatment of mild-to-moderate depression disorder under the supervision of a medical doctor, since, although it appears to be a potentially efficient treatment with a low presence of adverse effects in comparison to synthetic antidepressants, it might also interact with other medications and lead to therapeutic failures if misused for self-medication.
，也被称为圣约翰草、贯叶连翘或金丝桃，以其抗抑郁潜力而闻名。它可能是当前药理学抗抑郁治疗的一种天然替代方法，目前的抗抑郁治疗在患者中副作用发生率很高，因此导致早期停药。通过对2020年第一季度临床试验的文献综述以及从科学文章中收集的信息，我们旨在评估其给药是否对治疗轻至中度抑郁症有益，与合成药物相比副作用更少。在主要成分中，金丝桃素和贯叶连翘素与观察到的抗抑郁活性有关；因此，对它们可能的作用机制进行了综述并突出强调。此外，与接受旧的标准抗抑郁药的患者相比，接受提取物治疗的患者因不良反应而退出研究的可能性更小。本综述旨在为在医生监督下替代治疗轻至中度抑郁症提供建议，因为尽管与合成抗抑郁药相比，它似乎是一种潜在有效的治疗方法，副作用较少，但如果滥用进行自我用药，它也可能与其他药物相互作用并导致治疗失败。
