Lohuis J A, Verheijden J H, Burvenich C, van Miert A S
Department of Herd Health and Reproduction, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
Vet Q. 1988 Apr;10(2):109-16. doi: 10.1080/01652176.1988.9694157.
Data from the literature on the clinical effects of bacterial endotoxins in ruminants are reviewed. Special attention is paid to the effects on body temperature and reticulo-rumen motility. Furthermore, the effects of repeated intravenous injection of endotoxin are summarised. Pathophysiological disturbances after intramammary infusion of endotoxins proved to be identical to those found after intravenous injection of non-lethal doses. Strikingly, however, no marked inhibitory effect on rumen motility nor abortion was observed after intramammary infusion of endotoxins. Moreover, in cows that were made tolerant to endotoxin by daily intravenous injections, intramammary infusion of one-fifth of this daily dose produced a maximum effect on body temperature and plasma Zn concentrations. This suggests that inflammatory endogenous mediators were released in the udder and then absorbed into the blood circulation, rather than the absorption of endotoxin.
本文综述了关于反刍动物体内细菌内毒素临床效应的文献数据。特别关注了其对体温和瘤胃蠕动的影响。此外，还总结了重复静脉注射内毒素的效应。乳房内注入内毒素后的病理生理紊乱被证明与静脉注射非致死剂量后的情况相同。然而，引人注目的是，乳房内注入内毒素后未观察到对瘤胃蠕动的明显抑制作用，也未观察到流产现象。此外，在通过每日静脉注射使奶牛对内毒素产生耐受性的情况下，乳房内注入该日剂量的五分之一对体温和血浆锌浓度产生了最大影响。这表明炎症内源性介质是在乳房中释放，然后被吸收进入血液循环，而不是内毒素的吸收。
