奶牛内毒素血症：瘤胃积食的机制

Endotoxaemia in dairy cattle: mechanism of reticulorumen stasis.

作者信息

Eades S C

机构信息

Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.

出版信息

Vet J. 1997 May;153(3):321-7. doi: 10.1016/s1090-0233(97)80066-4.

DOI:10.1016/s1090-0233(97)80066-4

PMID:9232121

Abstract

The objective of this study was to determine whether blockade of alpha(-2) adrenergic receptors would restore reticulorumen motility during toxaemia in cows. Reticulorumen contractions were measured via a water-filled balloon connected to a pressure transducer. Intravenous infusion of endotoxin (100 ng kg-1 over 30 min) significantly decreased the number of reticulorumen contractions. Intravenous infusion of yohimbine (125 micrograms kg-1 over 30 min) alone did not affect reticulorumen contractions. However, when yohimbine (125 micrograms kg-1 over 30 min) was infused concurrently with endotoxin (100 ng kg-1 over 30 min), the effects of endotoxin on reticulorumen contraction frequency decreased, suggesting that endotoxaemia causes reticulorumen stasis via a mechanism that involves alpha(-2) adrenergic receptors.

摘要

本研究的目的是确定阻断α-2肾上腺素能受体是否能恢复奶牛毒血症期间瘤网胃的运动性。通过连接压力传感器的充水气球测量瘤网胃收缩。静脉输注内毒素（30分钟内100 ng/kg）显著减少瘤网胃收缩次数。单独静脉输注育亨宾（30分钟内125μg/kg）不影响瘤网胃收缩。然而，当育亨宾（30分钟内125μg/kg）与内毒素（30分钟内100 ng/kg）同时输注时，内毒素对瘤网胃收缩频率的影响降低，这表明内毒素血症通过涉及α-2肾上腺素能受体的机制导致瘤网胃停滞。