肌少症与肥胖。

Sarcopenia and obesity.

机构信息

Geriatric Division, Department of Medicine, University of Verona.

HealthyAging Center Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.

出版信息

Curr Opin Clin Nutr Metab Care. 2019 Jan;22(1):13-19. doi: 10.1097/MCO.0000000000000519.

Abstract

PURPOSE OF REVIEW

Together with age-related body composition changes, the increased prevalence of obesity observed in the past few decades in older individuals has led to a condition called sarcopenic obesity, characterized by a mismatch between muscle mass and fat mass. The operative definition of sarcopenic obesity is still under discussion and creates difficulties in clinical practice. Muscle weakness, rather than low muscle mass, was previously proposed as an alternative criterion and, more recently, the dynapenic abdominal obese phenotype is of increasing interest because of its unfavorable health consequences and usability in clinical practice.

RECENT FINDINGS

This review focuses on the most recent findings of pathogenic inter-relationships between adipose tissue and muscle. Recent studies on health consequences of sarcopenic obesity and dynapenic abdominal obesity are also examined. Despite the lack of consensus on a definition for sarcopenic obesity, progress has been made in the delineation of the treatment principles for this condition.

SUMMARY

Further research is needed to compare different definitions of sarcopenic/dynapenic obesity to clarify the relationship between obesity and the most important adverse outcomes in the elderly. The next step will be the definition of best possible therapeutic approaches for this condition.

摘要

目的综述

随着年龄相关的身体成分变化,过去几十年中老年人肥胖患病率的增加导致了一种称为肌少症性肥胖的情况,其特征是肌肉质量和脂肪质量之间不匹配。肌少症性肥胖的操作性定义仍在讨论中,并在临床实践中造成困难。肌肉无力,而不是低肌肉质量,以前被提出作为替代标准,最近,无力性腹部肥胖表型因其不利的健康后果和在临床实践中的可用性而引起越来越多的关注。

最新发现

本文综述了脂肪组织和肌肉之间的最新致病相互关系的发现。还研究了肌少症性肥胖和无力性腹部肥胖的健康后果的最新研究。尽管肌少症性肥胖的定义缺乏共识,但在确定该病症的治疗原则方面已经取得了进展。

总结

需要进一步研究比较不同的肌少症/无力性肥胖定义,以阐明肥胖与老年人最重要的不良结局之间的关系。下一步将是为这种情况定义最佳的治疗方法。

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