[基因多态性对免疫反应影响的研究进展]

[Progress in research of influence of gene polymorphisms on immune response].

作者信息

Cao J Q, Li J X, Wang Y Y, Zhu F C

机构信息

School of Public Health, Nanjing Medical University, Nanjing 211166, China.

Department of Vaccine Clinical Evaluation, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Nov 10;39(11):1515-1518. doi: 10.3760/cma.j.issn.0254-6450.2018.11.018.

DOI:10.3760/cma.j.issn.0254-6450.2018.11.018

PMID:30462964

Abstract

Genes play an important role in the immune system response, and different gene loci may result in different vaccine immune response rates. This review focuses on the correlation between gene polymorphisms and vaccine immune response in order to investigate the influence of gene polymorphisms on the immune response to vaccines. It discusses the effect of an individual's immune response after vaccination at genetic level and provides a scientific basis for individualized immune development strategies. It reveals that human leukocyte antigen genes, various cytokines and their receptor genes, and Toll-like receptor genes all affect the vaccine immune response.

摘要

基因在免疫系统反应中发挥着重要作用，不同的基因位点可能导致不同的疫苗免疫反应率。本综述聚焦于基因多态性与疫苗免疫反应之间的相关性，以研究基因多态性对疫苗免疫反应的影响。它在基因水平上探讨了个体接种疫苗后的免疫反应效果，并为个性化免疫发展策略提供科学依据。研究表明，人类白细胞抗原基因、各种细胞因子及其受体基因以及Toll样受体基因均会影响疫苗免疫反应。