Ovsyannikova Inna G, Dhiman Neelam, Jacobson Robert M, Poland Gregory A
Department of Internal Medicine, Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
Expert Rev Vaccines. 2006 Feb;5(1):33-43. doi: 10.1586/14760584.5.1.33.
Antibody formation in response to antigen stimulation remains the basis for measuring an individual's response and protection for most viral vaccines. A significant proportion of the variation in individual humoral immune response to vaccination appears to be genetic. The collection of genes found on chromosome 6 forming the human leukocyte antigen system provides one of the greatest sources of genetic variation in individuals with respect to their immunological responses. Recent research has demonstrated significant associations between vaccine response and human leukocyte antigen alleles. These associations not only explain why vaccine-induced humoral immune responses vary among individuals and between populations, but these variations may also hold the key to the development of future generations of vaccines.
针对抗原刺激产生抗体仍然是衡量个体对大多数病毒疫苗的反应和保护作用的基础。个体对疫苗接种的体液免疫反应中很大一部分变异似乎是由基因决定的。位于6号染色体上构成人类白细胞抗原系统的一组基因是个体免疫反应中最大的遗传变异来源之一。最近的研究表明，疫苗反应与人类白细胞抗原等位基因之间存在显著关联。这些关联不仅解释了为什么疫苗诱导的体液免疫反应在个体之间以及群体之间存在差异，而且这些差异可能也是下一代疫苗研发的关键所在。
