Department of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2S7, Canada.
School of Human Nutrition, McGill University, Ste. Anne de Bellevue, Quebec, H9X 3V9, Canada.
Cell Calcium. 2018 Dec;76:116-121. doi: 10.1016/j.ceca.2018.11.002. Epub 2018 Nov 10.
Endoplasmic reticulum (ER) luminal Ca influences many functions of this organelle, notably the synthesis and quality control of proteins and lipids. Cholesterol is an essential component of biological membranes and a precursor for many biologically important signaling molecules. The sterol regulatory element-binding proteins (SREBPs) are key regulators of lipid metabolism. These transcription factors are synthesized as ER membrane-bound precursor proteins that are proteolytically processed in response to cellular cholesterol status. Recently, ER Ca status was shown to be an important determinant of the basal sensitivity of the sterol sensing mechanism inherent to the SREBP processing pathway. This article discusses the emerging relationship between cellular Ca and cholesterol metabolism.
内质网（ER）腔中的 Ca 影响该细胞器的许多功能，特别是蛋白质和脂质的合成和质量控制。胆固醇是生物膜的重要组成部分，也是许多生物重要信号分子的前体。固醇调节元件结合蛋白（SREBPs）是脂质代谢的关键调节剂。这些转录因子作为 ER 膜结合的前体蛋白合成，这些前体蛋白在响应细胞胆固醇状态时被蛋白水解加工。最近，ER Ca 状态被证明是固醇感应机制固有 SREBP 加工途径的基础敏感性的重要决定因素。本文讨论了细胞 Ca 和胆固醇代谢之间新出现的关系。
