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除母乳以外的奶类与 3 岁儿童哮喘发病的关系:一项出生队列研究(2006-2011 年)

Milk Other Than Breast Milk and the Development of Asthma in Children 3 Years of Age. A Birth Cohort Study (2006⁻2011).

机构信息

Centre for Applied Health Economics, School of Medicine, Menzies Health Institute Queensland, Griffith University, QLD 4111, Australia.

Department of Public Health, College of Health Sciences, Qatar University, Doha 2713, Qatar.

出版信息

Nutrients. 2018 Nov 19;10(11):1798. doi: 10.3390/nu10111798.

Abstract

Prevalence of asthma in Australian children is amongst the highest in the world. Although breastfeeding positively influences infant immunity, early introduction of Milk Other than Breast Milk (MOTBM) may also play an important role in the development of Asthma. The aim of this study was to investigate the association between the introduction of MOTBM in the first six months after birth and the development of reported persistent asthma in 3-year olds. A sample of 1121 children was extracted from the Environments for Healthy Living longitudinal birth cohort study. Introduction of MOTBM during the first six months after birth increased almost two-fold the risk of development of persistent asthma after adjusting for other covariates (Adjusted Relative Risk (ARR): 1.71, 95% CI: 1.03⁻2.83, = 0.038). This study indicates that the introduction of MOTBM in the first six months of life is a risk factor for asthma incidence among 3-year old children. This result is important in explaining the benefits of breastfeeding as part of public health interventions to encourage mothers to increase breastfeeding initiation and duration, and avoid the introduction of MOTBM in the first six months after childbirth.

摘要

澳大利亚儿童的哮喘患病率位居世界前列。虽然母乳喂养对婴儿的免疫力有积极影响,但牛奶以外的其他代乳品(MOTBM)的早期引入也可能在哮喘的发展中发挥重要作用。本研究旨在调查出生后前六个月引入 MOTBM 与 3 岁儿童持续性哮喘发病之间的关联。从健康生活环境纵向出生队列研究中抽取了 1121 名儿童的样本。在调整了其他协变量后,出生后前六个月引入 MOTBM 使持续性哮喘发展的风险增加近两倍(调整后的相对风险 (ARR):1.71,95%CI:1.03-2.83,p=0.038)。本研究表明,出生后前六个月引入 MOTBM 是 3 岁儿童哮喘发病率的一个风险因素。这一结果对于解释母乳喂养的益处很重要,母乳喂养作为公共卫生干预措施的一部分,旨在鼓励母亲增加母乳喂养的开始和持续时间,并避免在孩子出生后的前六个月引入 MOTBM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9d6/6267177/770a2476c2cd/nutrients-10-01798-g001.jpg

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