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When and how to use predictive biomarkers for corticosteroid treatment of septic shock.

作者信息

Russell James A

机构信息

Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

Division of Critical Care Medicine, Vancouver, BC, V6Z 1Y6, Canada.

出版信息

Crit Care. 2018 Nov 21;22(1):318. doi: 10.1186/s13054-018-2254-z.

DOI:10.1186/s13054-018-2254-z
PMID:30463607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6249723/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/6249723/db35a4672520/13054_2018_2254_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/6249723/db35a4672520/13054_2018_2254_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/79b6/6249723/db35a4672520/13054_2018_2254_Fig1_HTML.jpg

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本文引用的文献

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Hydrocortisone plus Fludrocortisone for Adults with Septic Shock.氢化可的松联合氟氢可的松治疗脓毒性休克成人患者。
N Engl J Med. 2018 Mar 1;378(9):809-818. doi: 10.1056/NEJMoa1705716.
2
Adjunctive Glucocorticoid Therapy in Patients with Septic Shock.辅助糖皮质激素治疗脓毒性休克患者。
N Engl J Med. 2018 Mar 1;378(9):797-808. doi: 10.1056/NEJMoa1705835. Epub 2018 Jan 19.
3
Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017.
危重病相关皮质激素不足（CIRCI）的诊断和管理指南（第一部分）：危重病医学会（SCCM）和欧洲危重病医学会（ESICM）2017 年。
Intensive Care Med. 2017 Dec;43(12):1751-1763. doi: 10.1007/s00134-017-4919-5. Epub 2017 Sep 21.
4
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.拯救脓毒症运动：脓毒症与脓毒性休克管理国际指南：2016版
Crit Care Med. 2017 Mar;45(3):486-552. doi: 10.1097/CCM.0000000000002255.
5
Unique Transcriptional Programs Identify Subtypes of AKI.独特的转录程序可识别急性肾损伤的亚型。
J Am Soc Nephrol. 2017 Jun;28(6):1729-1740. doi: 10.1681/ASN.2016090974. Epub 2016 Dec 27.
6
Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial.血管加压素与去甲肾上腺素对感染性休克患者肾衰竭影响的随机临床试验：VANISH 研究。
JAMA. 2016 Aug 2;316(5):509-18. doi: 10.1001/jama.2016.10485.
7
Plasma cytokine levels predict response to corticosteroids in septic shock.血浆细胞因子水平可预测脓毒性休克对皮质类固醇的反应。
Intensive Care Med. 2016 Dec;42(12):1970-1979. doi: 10.1007/s00134-016-4338-z. Epub 2016 Apr 12.
8
Readmission diagnoses after hospitalization for severe sepsis and other acute medical conditions.因严重脓毒症和其他急性病症住院后的再入院诊断。
JAMA. 2015 Mar 10;313(10):1055-7. doi: 10.1001/jama.2015.1410.
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An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation.内毒素耐受特征可预测脓毒症及初次临床表现时的器官功能障碍。
EBioMedicine. 2014 Nov 1;1(1):64-71. doi: 10.1016/j.ebiom.2014.10.003.
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Gene expression profiling in sepsis: timing, tissue, and translational considerations.脓毒症中的基因表达谱分析：时机、组织及转化医学考量
Trends Mol Med. 2014 Apr;20(4):204-13. doi: 10.1016/j.molmed.2014.01.006. Epub 2014 Feb 15.