Ismaeel Ahmed, Lavado Ramon, Smith Robert S, Eidson Jack L, Sawicki Ian, Kirk Jeffrey S, Bohannon William T, Koutakis Panagiotis
Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, Florida.
Department of Environmental Science, Baylor University, Waco, Texas.
J Surg Res. 2018 Dec;232:503-509. doi: 10.1016/j.jss.2018.07.024. Epub 2018 Aug 3.
Revascularization procedures to treat patients with peripheral artery disease are among the most common operations performed by vascular surgeons. However, there are major limitations to revascularizations, readmission rates due to procedural complications are high, and greater risks of cardiovascular and limb adverse outcomes have been reported for patients with peripheral artery disease undergoing limb revascularization. Specifically, surgical revascularization may be associated with increased generation of reactive oxygen species based on the ischemia reperfusion injury theory, as restored blood flow and reoxygenation of ischemic areas may be accompanied by increased oxidative stress. In this review, we present the current evidence regarding the effects of revascularization procedures on oxidative stress. We also discuss potential therapeutic interventions to prevent ischemia reperfusion injury-mediated tissue damage.
治疗外周动脉疾病患者的血运重建手术是血管外科医生最常进行的手术之一。然而，血运重建存在重大局限性，因手术并发症导致的再入院率很高，并且有报道称，接受肢体血运重建的外周动脉疾病患者发生心血管和肢体不良后果的风险更大。具体而言，根据缺血再灌注损伤理论，外科血运重建可能与活性氧生成增加有关，因为缺血区域血流恢复和再氧合可能伴随着氧化应激增加。在本综述中，我们展示了关于血运重建手术对氧化应激影响的当前证据。我们还讨论了预防缺血再灌注损伤介导的组织损伤的潜在治疗干预措施。
