丙戊酸盐诱发的癫痫女童多囊卵巢综合征：病例报告
Valproate-Induced Polycystic Ovary Syndrome in a Girl with Epilepsy: A Case Study.
作者信息
Kawakami Yasuhiko, Fujii Shuichi, Ishikawa Gen, Sekiguchi Atsuko, Nakai Akihito, Takase Masato
机构信息
Department of Pediatrics, Nippon Medical School Musashi Kosugi Hospital.
Department of Pediatrics, Nippon Medical School Tama Nagayama Hospital.
出版信息
J Nippon Med Sch. 2018;85(5):287-290. doi: 10.1272/jnms.JNMS.2018_85-46.
BACKGROUND
Polycystic ovary syndrome (PCOS) is a common ovulatory disorder that can be induced by sodium valproate (VPA).
PATIENT
We report a case of PCOS that developed in a 15-year-old girl with idiopathic epilepsy after she took VPA. VPA administration stopped her seizures, but it also led to weight gain and amenorrhea, and the patient was diagnosed with PCOS on the basis of diagnostic imaging and serological examination results. Cessation of VPA administration led to reduced weight gain and restored menstruation.
CONCLUSIONS
The risk of PCOS developing in patients with epilepsy is known to be high, and the association of VPA with PCOS is well established, so if physicians feel this is the best drug to prescribe for female patients with epilepsy, they should carefully monitor the patients' weight and menstruation, and immediately perform ovarian imaging and hormonal examinations if any abnormalities are observed.
背景
多囊卵巢综合征（PCOS）是一种常见的排卵障碍疾病，可由丙戊酸钠（VPA）诱发。
患者
我们报告一例15岁特发性癫痫女孩在服用VPA后发生PCOS的病例。服用VPA使她的癫痫发作停止，但也导致体重增加和闭经，根据诊断性影像学检查和血清学检查结果，该患者被诊断为PCOS。停用VPA导致体重增加减轻且月经恢复。
结论
已知癫痫患者发生PCOS的风险较高，且VPA与PCOS之间的关联已得到充分证实，因此，如果医生认为这是为癫痫女性患者开的最佳药物，他们应仔细监测患者的体重和月经情况，一旦观察到任何异常，应立即进行卵巢影像学检查和激素检查。
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