生存素基因c.-31G>C（rs9904341）颠换与泌尿系统癌症风险：一项系统评价和荟萃分析。

Survivin c.-31G>C (rs9904341) gene transversion and urinary system cancers risk: a systematic review and a meta-analysis.

作者信息

Mazoochi Tahereh, Karimian Mohammad, Ehteram Hassan, Karimian Ali

机构信息

Anatomical Sciences Research Center, Kashan University of Medical Sciences, Kashan, Iran.

Gametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran.

出版信息

Per Med. 2019 Jan;16(1):67-78. doi: 10.2217/pme-2018-0053. Epub 2018 Nov 22.

DOI:10.2217/pme-2018-0053

PMID:30465472

Abstract

AIM

To investigate the possible association between survivin c.-31G>C (rs9904341) gene polymorphism and urinary system cancers by a meta-analysis approach.

METHODS

Standard electronic literature databases were searched to find eligible studies. The odds ratios (ORs) with 95% CIs were estimated to find the associations possibility.

RESULTS

Overall meta-analysis revealed significant associations between c.-31G>C transversion and risk of urinary tract cancers in dominant (OR: 1.34; 95% CI: 1.02-1.75; p = 0.035), recessive (OR: 1.52; 95% CI: 1.33-1.74; p < 0.001) and homozygote codominant (OR: 1.90; 95% Cl: 1.37-2.62; p < 0.001) genetic models.

CONCLUSION

The c.-31G>C transversion might be a risk factor for urinary system cancers. However, more articles with different ethnicities will help to obtain a more accurate conclusion.

摘要

目的

采用荟萃分析方法探讨生存素基因c.-31G>C（rs9904341）多态性与泌尿系统癌症之间可能存在的关联。

方法

检索标准电子文献数据库以查找符合条件的研究。估计比值比（OR）及其95%置信区间（CI）以确定关联可能性。

结果

总体荟萃分析显示，在显性遗传模型（OR：1.34；95%CI：1.02 - 1.75；p = 0.035）、隐性遗传模型（OR：1.52；95%CI：1.33 - 1.74；p < 0.001）和纯合子共显性遗传模型（OR：1.90；95%CI：1.37 - 2.62；p < 0.001）中，c.-31G>C颠换与尿路癌症风险之间存在显著关联。