Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Shenyang 110016, P. R. China.
Org Biomol Chem. 2018 Dec 5;16(47):9147-9151. doi: 10.1039/c8ob02582g.
A unique gold(i)-catalyzed 5-endo-dig cyclization/aerobic oxidation cascade strategy from 1,5-enyne substrates with molecular oxygen as the oxidant to yield the indenone was described. The reaction mechanism was studied by heavy atom labelling and some related experiments. This method was applied to the formal total synthesis of isoprekinamycin.
描述了一种独特的金(i)催化的 5-endo-内型环化/有氧氧化级联策略，该策略以 1,5-烯炔底物为原料，以分子氧为氧化剂，生成茚酮。通过重原子标记和一些相关实验研究了反应机理。该方法被应用于异普雷霉素的正式全合成。
