使用金（I）催化的 3-甲氧基-1,6-烯炔的环异构化作为关键策略，对克拉乌菌素 A 进行外消旋形式的全合成。
A racemic formal total synthesis of clavukerin A using gold(I)-catalyzed cycloisomerization of 3-methoxy-1,6-enynes as the key strategy.
机构信息
Department of Chemistry, POSTECH (Pohang University of Science and Technology), Hyoja-dong san 31, Nam-gu, Pohang, Kyungbook, Republic of Korea 790-784.
出版信息
Beilstein J Org Chem. 2011;7:740-3. doi: 10.3762/bjoc.7.84. Epub 2011 Jun 1.
Abstract
An efficient formal total synthesis of (±)-clavukerin A was accomplished via a gold-catalyzed cycloisomerization of a 3-methoxy-1,6-enyne 5 as the key strategy followed by Rh-catalyzed stereoselective hydrogenation of the cycloheptenone 4.
摘要
通过金催化的 3-甲氧基-1,6-烯炔 5 的环化异构化作为关键策略，实现了（±）-克拉乌菌素 A 的有效全合成，随后通过 Rh 催化的环庚烯酮 4 的立体选择性氢化。
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